I have to write a 500 word research proposal for the topic: A review of immune checkpoint inhibitors in non-small cell lung cancer. The rubric attached explains how the proposal must be written and i have attached an example to help with layout and how much detail is needed.
My research question is: Are there novel targets for immune checkpoint inhibitors that could offer increased efficacy and safety in non-small cell lung cancer beyond those currentlyapproved?
The aim is: Systematically review the literature of current and potentioal immune checkpoint inhibitor targets for non-small cell lung cancer to provide an in-depth analysis of the highest safety and efficacy to improve patient survival outcome.
I will do this by:
•Identify potential alternative targets.
•Collect safety and efficacy data from pivotal clinical trials that lead to the registration of the most common ICI drugs for NSCLC.
•Compare with emerging data from Phase I/II/III clinical trials for new targeted therapies.
•Discuss the advantages and disadvantages of the new therapeutic targets.
•Discuss ability of monotherapy ICI’s becoming gold standard for treatment NSCLC.
so the point of this paper is that i will be focusing on the 2 most common drugs for each target: PD-1, PD-L1, CTLA4.
however, as some of these have been in the market for years, i will only use the data from their pivotal clinical trials that lead to their registration, ( so their phase I/II/III) data to compare to the new other potential targets ( such as EGFR receptors or anaplastic lymphoma kinase inhibitor…)currently undergoing Phase I/II/II so that the data is fair. It would be unfair to use the years of data available for older drugs and compare them with the limited new data for upcoming potential drugs.
please pick either 2 drugs for 3 novel targets. – please also try to use drugs that are in the later phases so that more data is available
Therefore, there should be a total of 12 drugs, 6 already on the market and 6 in the clinical phases.
Please also note that i will be focused only on Monotherapy drug, the only exception are CTLA-4 drugs that must be used with another ici.
All drugs must be targets for non-small cell lung cancer.
Knowledge gap, project motivation and impact:
•The optimal treatment approach for non-small cell lung cancer remains unknown
•Current ICI treatment remains ineffective for some NSCLC patients
•New therapeutic targets and treatment strategies may increase patient survival
•Provide valuable insights into optimizing treatment strategies for NSCLC patients
•Lead to improved clinical outcomes and enhanced patient care.
You will probably have to expand on the above points or add more when it comes toanswering the rubric.
The method must also be described as this is a literature review so my methodoly and and methods must be highlighted and justified.
I will attach a rubric that MUST be reffered to when writing this proposal.
there is a strong 500 word limit +-5% and absolutely no more than 5 references to be used.
I will also attach examples my proffesor has provided me with so that you can see the layout and level of detail is required.
Please feel free to ask me any questions about my project if unsure, thank you.
