Heat Shock Protein 47 is found in many animals and when reduced, serves as nature’s potent anticoagulant. That is why bears don’t get blood clots when hibernating, pigs don’t get clots after birthing and why people with spinal cord injuries don’t get clots either. The paper that I need written is a compilation of all research that has been done about Heat Shock Protein 47. The main question that I presented is, “Can HSP47 be used in future medical treatments, or is the protein simply bound to serve as nature’s Asprin?
Introduction, Methods, and Discussion (150 pts), of those:
**The questions below are just to guide you – don’t repeat them in your paper, please. Please, no numbering either**
1) What is your question?
Identify the question that you investigated (30)
2) Why it is interesting? Why do we care?
Elaborate on why you think that this question was interesting and worth pursuing, cite appropriate references (30)
3) What did you/the authors do to answer the question and why?
Explain in detail the hypotheses and predictions that you examined/tested, cite appropriate references (30)
4) What did you/the authors find?
Describe what you found. What data did you accumulate, what conclusions you have drawn from these data. Do the conclusions agree with the predictions? Did you find support for your hypotheses? Explain. (30)
5) What has been done in this area?
Describe how your results and conclusions are related to previous research that has been done in this area – cite relevant references. What are the prevalent hypotheses and explanations for the question that you have investigated? Why? (30)
Thienel, Manuela, et al. “Immobility-associated thromboprotection is conserved across mammalian species from bear to human.” Science, vol. 380, no. 6641, 14 Apr. 2023, pp. 178–187, https://doi.org/10.1126/science.abo5044.
“Heat shock protein inhibitors.” Topics in Medicinal Chemistry, 2016, https://doi.org/10.1007/978-3-319-32607-8.
Ito, Shinya, and Kazuhiro Nagata. “Roles of the endoplasmic reticulum–resident, collagen-specific molecular chaperone HSP47 in vertebrate cells and human disease.” Journal of Biological Chemistry, vol. 294, no. 6, Feb. 2019, pp. 2133–2141, https://doi.org/10.1074/jbc.tm118.002812.
