Overview
Certain drugs used primarily in human medicine can be used under certain circumstances in animals. However, there are some that must be used with caution or not at all in an animal due to their toxicity profile. The following project is intended for you to investigate the effects of a specific human drug that is toxic in dogs. Explore the drug mechanism and dog physiology factors that contribute to toxicity, and the treatment approach to toxicosis. This project relates to the material you have learned regarding pharmacology (and toxicology) principals, recognition of drug-related clinical signs, and appropriate approaches to these.
Instructions
You work in a veterinary hospital where a few clients have presented dogs with illnesses after they were given or accidentally ingested isoniazid tablets that belonged to clients taking these tablets for their own tuberculosis infections. In most cases, a dog had clinical signs after ingesting one or more 300 mg isoniazid tablets, one of these cases proved fatal. The hospital is collaborating with other veterinary clinics and hospitals that have reported similar cases of isoniazid overdoses in dogs.
Students are required to write a research paper discussing isoniazid overdose in dogs. The paper must address the five components listed below.
Explain the mechanism of isoniazid’s antimicrobial action and how this relates to toxicity in dogs
Discuss the unique dog biochemistry that promotes isoniazid toxicity in dogs
Identify the organ systems affected by isoniazid toxicity in dogs and describe clinical signs associated with the effects on these organ systems
Describe the primary treatment approach to isoniazid toxicity and the antidote for isoniazid toxicosis.
Explain the mechanism of action of the antidote used when treating isoniazid toxicity
Project Specifications
You must turn in a single word-processing document, 3-6 pages in length, using Times New Roman size 12 font, double spaced with normal 1” margins
The title page should contain the following information:
The Title: Vet 305 Advanced Veterinary Pharmacology
Your Name
Your student ID number
Your email address
The date the project was submitted
The paper must address the five required components.
The paper should be easy to read with correct spelling, grammar, and punctuation.
The paper should include a minimum of four references listed in APA format at the end of the document on a references page. Each reference should have corresponding in-text citations. You can use the course textbook as one reference, but you’ll need at least three other outside references. Sources used should be from medical publications or websites. Do not use sites like Wikipedia.
Summary
Explore the drug mechanism and dog physiology factors that contribute to toxicity, clinical signs of toxicity, and the treatment approach to isoniazid toxicosis.
